In August 1484 the Pope dies. The woman will marry in secret with a man of humble origins, Giacomo Feo, after the death of her first husband. After the death of Feo in an ambush, Caterina Sforza will marry for the third time in 1497 with Giovanni de' Medici.
The years pass and we find ourselves in 1498 with Pope Alexander VI Borgia who begins the annexation of Romagna to the Papal State with the siege of the troops of Cesare Borgia, son of the pontiff: Caterina Borgia is captured and tries to escape but is accused of having attempted to kill the Pope through letters soaked in poison and imprisoned in Castel Sant'Angelo.
From the windows of her prison she is forced to watch the execution of 18 people accused of various crimes, to make her fear for her fate. The Pope and Cesare Borgia probably want the woman to die of natural causes, not daring to kill her, but mistreating her and providing her with little nourishment. They do not want to interrupt the negotiations begun with the Riario and the Medici for her release, in which her brother-in-law, Maximilian I of Habsburg, her sister's husband, is also interested. In 1501 the French army, in the name of the King of France, asks for the release of the countess, who after a year and four months of harsh imprisonment is finally freed. Caterina takes refuge and dedicates her last years to her family and studies. She dies in May 1509